PhytoChemistry

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    Our research group employs a multidisciplinary approach at the interface of chemistry and biology to decipher the molecular insights of life and decode complex pharmacological mechanisms. By synergizing methodologies from Phytochemistry, (Bio)Analytical Chemistry, Plant Extracellular Vesicle Biochemistry, Sustainable Solvents (Natural Deep Eutectic Solvents), and Biological Mass Spectrometry (Proteomics, Metabolomics, and Lipidomics), supported by integrated in silico, in vitro, and in vivo models, we drive innovation in drug discovery and therapeutic development. Core Research Domains Theme 1: Plant Extracellular Vesicles (PEVs): Next-Generation Natural Nanomedicine Platform Exploitation of plant-derived extracellular vesicles for targeted drug delivery, biomolecular cargo profiling, and nanomedicine applications. Theme 2: Green Molecular Pharmaceutics: Smart NADES and THEDES Design and application of Smart Natural Deep Eutectic Solvents (Smart NADES) and Therapeutic Deep Eutectic Solvents (THEDES) for sustainable extraction, stabilization, and enhanced delivery of bioactive molecules. Theme 3: AI-Enabled, Bioactivity-Guided Discovery Platform for Next-Generation Botanical Drugs Integration of artificial intelligence, high-resolution analytical workflows, and multi-omic data analytics to accelerate the rational discovery and validation of botanical therapeutics. For more information, please visit our group page: https://sites.google.com/view/shivpatilresearchgroup/home
  • B.Sc. Biochemistry
  • M.Sc. Biochemistry
  • Ph.D. Biological Sciences
  • Post Doctoral Proteomics and Mass Spectrometry
  • CSIR-IHBT, Palampur, Phytochemistry - PostDoc (February 2022- January 2023 )
  • University of North Carolina, Proteomics - PostDoc (January 2023- February 2026 )
  • CSIR-CIMAP, Lucknow, Phytochemistry - Scientist C (June 2026- till date )
  • Junior Research Fellowship,PhDby CSIR in 2017-2022
  • Patil, S. S., & Zhang, Q. Impact of preanalytical factors on plasma extracellular vesicles and human plasma proteome.. Clinical Proteomics 2026
  • Patil, S. S., & Zhang, Q. Comprehensive Comparison of Methods for Isolation of Extracellular Vesicles from Human Plasma.. Journal of Proteome Research 2025
  • Patil, S. S., Sun, X., Zhou, Z., & Zhang, Q.. Spatial Proteomics Reveals Alcohol-Induced Damages to the Crypts and Villi of the Mouse Small Intestine. Journal of Proteome Research 2024
  • Patil, S. S., Anmol, & Sharma, U.. Implementing sustainable methods in natural products research.. Trends in Chemistry 2024
  • Patil, S. S., Kumari, S., Sahal, D., & Sharma, U.. Innate functions of natural products: a promising path for identification of novel therapeutics.. European Journal of Medicinal Chemistry 2023
  • Patil, S. S., Singh, P. P., Sharma, M., & Sharma, U.. Multicomponent natural deep eutectic solvents: Super solvents for the efficient extraction of steviol glycosides (rebaudioside A) from Stevia rebaudiana. . Journal of Cleaner Production 2023
  • Patil, S. S., Kesarwani, V., Kumari, S., Shankar, R., & Sharma, U.. Bisbenzylisoquinolines from Cissampelos pareira L. as antimalarial agents: Molecular docking, pharmacokinetics analysis, and molecular dynamic simulation studies. . Computational Biology and Chemistry 2023
  • Patil, S. S., Thakur, K. G., & Sharma, U. . Molecular docking and dynamic simulation approach to decipher steroidal sapogenins (genus Trillium) derived agonists for glucocorticoid receptor. . Journal of Biomolecular Structure and Dynamics 2023