Plant Biotechnology

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    Plants produce an amazing diversity of specialized (i.e. secondary) metabolites that have applications as pharmaceuticals, pesticides, flavours and fragrances. These metabolites are biosynthesized and accumulated in tissue, organ and developmentally-specific manners, and also in response to pathogen attack and environmental perturbation, involving highly complex and sophisticated biosynthetic pathways. Comprehensive knowledge of the biosynthetic pathways and their regulation is pivotal to overcoming the low abundance of metabolites in natural hosts and producing them in heterologous hosts following modulation of the biosynthetic pathways. Our lab is interested in investigating the biosynthetic pathway enzymes and regulators that determine spatio-temporal accumulation of medicinally important metabolites in plants, which are acclaimed in traditional medicine. Our current research includes unraveling plant terpene biosynthetic pathways and pathway engineering to reconstruct terpene pathways in alternate plant and microbial hosts.
  • Ph.D.
  • National Institute of Plant Genome Research, New Delhi, - Post-Doctoral Fellow (2009- 2011 )
  • CSIR-CIMAP, Lucknow, - Scientist Fellow (2011- 2013 )
  • CSIR-CIMAP, Lucknow, - Senior Scientist (2013- 2016 )
  • University of Hamburg, Germany , - Visiting Scientist (2017- 2017 )
  • CSIR-CIMAP, Lucknow, - Principal Scientist (2016- 2020 )
  • CSIR-CIMAP, Lucknow, - Senior Principal Scientist (2020- till date )
  • Innovative Young Biotechnologist Award ,by Department of Biotechnology in 2015
  • Young Scientist Award ,by Council of Scientific and Industrial Research in 2015
  • Medal for Young Scientists ,by Indian National Science Academy in 2015
  • Young Scientist Platinum Jubilee Award ,by National Academy of Sciences, India in 2014
  • First position in M.Sc. (Ag.) in Genetics,by Bidhan Chandra Krishi Viswavidyalaya in 2003
  • Srivastava P, Garg A, Misra RC, Chanotiya CS, Ghosh . UGT86C11 is a novel plant UDP-glycosyltransferase involved in labdane diterpene biosynthesis. Journal of Biological Chemistry 2021
  • Kumar A, Srivastava P, Srivastava G, Sandeep, Kumar N, Chanotiya CS, Ghosh S . BAHD acetyltransferase contributes to wound-induced biosynthesis of oleo-gum resin triterpenes in Boswellia. The Plant Journal 2021
  • Srivastava G, Sandeep, Garg A, Misra RC, Chanotiya CS, Ghosh S. Transcriptome analysis and functional characterization of oxidosqualene cyclases of the arjuna triterpene saponin pathway. Plant Science 2020
  • Misra RC, Sharma S, Garg A and Ghosh S . Virus Induced Gene Silencing in Sweet basil (Ocimum basilicum). Virus-Induced Gene Silencing in Plants: Methods and Protocols. Eds: Courdavault V, Besseau S. Methods in Molecular Biology, Springer 2020
  • Sandeep and Ghosh S . Triterpenoids: structural diversity, biosynthetic pathway and bioactivity. Studies in Natural Products Chemistry. Ed: Atta-ur-Rahman. Elsevier. Volume 67 2020
  • Sandeep, Misra RC, Chanotiya CS, Mukhopadhyay P, Ghosh S. Oxidosqualene cyclase and CYP716 enzymes contribute to triterpene structural diversity in the medicinal tree banaba. New Phytologist 2019
  • Ghosh S. Triterpene Functional Genomics in Ocimum. The Ocimum Genome. Eds: Ajit K. Shasany, Chittaranjan Kole. Springer, Cham 2018
  • Ghosh S, Irfan M and Datta A . Improving Industrial Traits through RNA Silencing. Plant Gene Silencing: Mechanisms and Applications. Ed: Dalmay Tamas. CABI Biotechnology series books 2017
  • Misra RC, Sharma S, Sandeep, Garg A, Chanotiya CS, Ghosh S. Two CYP716A subfamily cytochrome P450 monooxygenases of sweet basil play similar but nonredundant roles in ursane- and oleanane-type pentacyclic triterpene biosynthesis. New Phytologist 2017
  • Ghosh S. Triterpene Structural Diversification by Plant Cytochrome P450 Enzymes. Frontiers in Plant Science 2017
  • Datta A and Ghosh S . Agricultural Biotechnology for Food Sufficiency and Benefit to Human Health- Chapter No. 72. Textbook of Biochemistry, Biotechnology, Allied & Molecular Medicine, under Section VIII, Human Genetics, Biochemical Basis of Inheritance, Expression of Genetic Information, Genetic Engineering. Eds: Talwar GP, Hasnain Seyed E, Sarin Shiv K. Prentice Hall of India 2015

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