Name : Dr. Sumit Ghosh Designation : Chief Scientist Address : CSIR-Central Institute of Medicinal and Aromatic Plants, Near Kukrail Picnic Spot, PO-CIMAP, Lucknow-226015, India E. mail : sumitghosh[dot]cimap[at]csir[dot]res[dot]in Contact No : 9565030235 Epabx No. : 518 Download Resume Area of Specialization Plants produce an amazing diversity of specialized (i.e. secondary) metabolites that have applications as pharmaceuticals, pesticides, flavours and fragrances. These metabolites are biosynthesized and accumulated in tissue, organ and developmentally-specific manners, and also in response to pathogen attack and environmental perturbation, involving highly complex and sophisticated biosynthetic pathways. Comprehensive knowledge of the biosynthetic pathways and their regulation is pivotal to overcoming the low abundance of metabolites in natural hosts and producing them in heterologous hosts following modulation of the biosynthetic pathways. Our lab is interested in investigating the biosynthetic pathway enzymes and regulators that determine spatio-temporal accumulation of medicinally important metabolites in plants, which are acclaimed in traditional medicine. Our current research includes unraveling plant terpene biosynthetic pathways and pathway engineering to reconstruct terpene pathways in alternate plant and microbial hosts. Lab webpage: https://sumitg80.wixsite.com/website Education B.Sc. Agriculture M.Sc. Ag. Genetics Ph.D. Plant Biochemistry & Biotechnology Academic/Research Experience CSIR-CIMAP, Lucknow, Plant Biotechnology - Senior Principal Scientist (January 2020- January 2025 ) National Institute of Plant Genome Research, New Delhi, - Post-Doctoral Fellow (June 2009- April 2011 ) CSIR-CIMAP, Lucknow, Plant Biotechnology - Scientist Fellow (April 2011- January 2013 ) CSIR-CIMAP, Lucknow, Plant Biotechnology - Senior Scientist (January 2013- January 2016 ) University of Hamburg, Germany , - Visiting Scientist (2017- 2017 ) CSIR-CIMAP, Lucknow, Plant Biotechnology - Chief Scientist (January 2025- till date ) CSIR-CIMAP, Lucknow, Plant Biotechnology - Principal Scientist (January 2016- January 2020 ) Honours and Awards Fellow of The National Academy of Sciences , India (FNASc),by in 2023 Innovative Young Biotechnologist Award ,by Department of Biotechnology in 2015 Young Scientist Award ,by Council of Scientific and Industrial Research in 2015 Medal for Young Scientists ,by Indian National Science Academy in 2015 Young Scientist Platinum Jubilee Award ,by National Academy of Sciences, India in 2014 First position in M.Sc. (Ag.) in Genetics,by Bidhan Chandra Krishi Viswavidyalaya in 2003 Publication Vyas P, Srivastava P, Srivastava G, Kumar A, Garg A, C H R, Ghosh S. UGT73FB1 contributes to scaffold-selective biosynthesis of triterpenoid glucosyl esters in saponin-rich bark of arjuna tree. Plant Journal 2025 Srivastava G, Vyas P, Kumar A, Singh A, Bhargav P, Dinday S, Ghosh S. Unraveling the role of cytochrome P450 enzymes in oleanane triterpenoid biosynthesis in arjuna tree. Plant Journal 2024 Garg A, Srivastava P, Verma PC, Ghosh S. ApCPS2 contributes to medicinal diterpenoid biosynthesis and defense against insect herbivore in Andrographis paniculata. Plant Science 2024 Sharma S, Chaurasia S, Dinday S, Srivastava G, Singh A, Chanotiya CS, Ghosh S. High-level biosynthesis of enantiopure germacrene D in yeast.. Applied Microbiology and Biotechnology 2024 Bhargav P, Chaurasia S, Kumar A, Srivastava G, Pant Y, Chanotiya CS, Ghosh S. Unraveling the terpene synthase family and characterization of BsTPS2 contributing to (S)-(?+)-linalool biosynthesis in Boswellia. Plant Molecular Biology 2023 Dinday S, Ghosh S. Recent advances in triterpenoid pathway elucidation and engineering. Biotechnology Advances. Biotechnology Advances 2023 Ghosh S. Enantioselective terpene emission signifies forest climate response mechanism. Trends in Plant Science 2023 Srivastava P, Garg A, Misra RC, Chanotiya CS, Ghosh . UGT86C11 is a novel plant UDP-glycosyltransferase involved in labdane diterpene biosynthesis. Journal of Biological Chemistry 2021 Kumar A, Srivastava P, Srivastava G, Sandeep, Kumar N, Chanotiya CS, Ghosh S . BAHD acetyltransferase contributes to wound-induced biosynthesis of oleo-gum resin triterpenes in Boswellia. The Plant Journal 2021 Srivastava G, Sandeep, Garg A, Misra RC, Chanotiya CS, Ghosh S. Transcriptome analysis and functional characterization of oxidosqualene cyclases of the arjuna triterpene saponin pathway. Plant Science 2020 Sandeep, Misra RC, Chanotiya CS, Mukhopadhyay P, Ghosh S. Oxidosqualene cyclase and CYP716 enzymes contribute to triterpene structural diversity in the medicinal tree banaba. New Phytologist 2019 Misra RC, Sharma S, Sandeep, Garg A, Chanotiya CS, Ghosh S. Two CYP716A subfamily cytochrome P450 monooxygenases of sweet basil play similar but nonredundant roles in ursane- and oleanane-type pentacyclic triterpene biosynthesis. New Phytologist 2017 Ghosh S. Triterpene structural diversification by plant cytochrome P450 enzymes. Frontiers in Plant Science 2017 Ghosh S. Biosynthesis of structurally diverse triterpenes in plants: the role of oxidosqualene cyclases. Proceedings of the Indian National Science Academy 2016 Misra RC, Garg A, Roy R, Vasudev PG, Chanotiya CS and Ghosh . Involvement of an ent-copalyl diphosphate synthase in tissue-specific accumulation of specialized diterpenes in Andrographis paniculata. Plant Science 2015 Garg A, Agrawal L, Misra RC, Sharma S, and Ghosh S. Andrographis paniculata transcriptome provides molecular insights into tissue-specific accumulation of medicinal diterpenes. BMC Genomics 2015 Misra RC, Maiti P, Chanotiya CS, Shanker K and Ghosh S. Methyl jasmonate-elicited transcriptional responses and pentacyclic triterpene biosynthesis in sweet basil. Plant Physiology 2014 Patents File No Title Inventors Patent No. Abstract Application No. 202311037138, dated 29.05.23 Genetically engineered yeasts and use thereof for de novo production of enantiopure germacrene D Ghosh S, Sharma S, Chaurasia S, Sandeep, Srivastava G, Singh A, Chanotiya CS Filed/Application No. 202311037138, dated 29.05.23/ The invention relates to engineered yeasts (Saccharomyces cerevisiae) that produce germacrene D at a high titer.