In-vivo Testing Facility

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    We are exploring the vasorelaxation and anti-hypertensive activity of novel medicinal plant derived molecules and extracts using ex-vivo, in-vitro and in-vivo models. Role of potassium channels, calcium channels, protein kinases etc. are explored as a mechanism of action studies. We are using SHRs, L-NAME and DOCCA models for in-vivo evaluation of the lead molecules. Techniques and tools like animal physiograph, dual chamber wire myograph, non-invasive and invasive measurement of hemodynamics, rodent ECG, smooth muscle cell culture, fluorescence based intracellular calcium and potassium imaging etc are used to study the proof of the concept. We also explore the potential of natural molecules against vascular hyporeactivity and hypotension in sepsis using caecal ligation and puncture based surgical model in mice.
  • B.V.Sc & A.H Veterinary and Animal Sciences
  • M.V.Sc Veterinary Pharmacology and Toxicology
  • Ph.D. Veterinary Pharmacology and Toxicology
  • National Scholarship ,by Ministry of Human Resource Development in 1994-1999
  • University Merit Scholarship,by University in 1999-2001
  • Senior Research Fellowship ,Doctoral Program in Pharmacologyby Indian Veterinary Research Institute in 2002-2005
  • Postdoctoral fellowship ,Postdoctoral by University of Maryland, Baltimore in 2005-
  • DBT-CREST Fellowship ,postdoctoral trainingby DBT in 2012-2013
  • Visiting Fellow ,by DBT in -2018
  • Moon Jain, Hina Iqbal, Pankaj Yadav, Himalaya Singh, Debabrata Chanda, Kumaravelu Jagavelu, Kashif Hanif. Autophagy inhibition by chloroquine prevents increase in blood pressure and preserves endothelial functions. Tropical Journal of Pharmaceutical Research 2020
  • Iqbal H, Yadav P, Verma AK, Mishra D, Vamadevan B, Singh D, Luqman S, Negi AS, Chanda D. Anti-inflammatory, anti-oxidant and cardio-protective properties of novel fluorophenyl benzimidazole in L-NAME-induced hypertensive rats. European Journal of Pharmacology 2022
  • Yadav P, Iqbal H, Kumar K, Kumar P, Mishra D, Singh A, Pal A, Mukhopadhyay P, Vamadevan B, Singh D, Negi AS, Chanda D. 2-Benzyllawsone protects against polymicrobial sepsis and vascular hyporeactivity in swiss albino mice. European Journal of Pharmacology 2022
  • Iqbal, H., Verma, AK., Yadav, P., Alam, S., Shafiq, M., Mishra, D., Khan, F., Hanif, K., negi, AS., Chanda, D. Antihypertensive effect of a novel angiotensin II receptor blocker fluorophenyl benzimidazole: contribution of cGMP, voltage-dependent calcium channels and BKCa channels to vasorelaxant mechanisms. Frontiers in Pharmacology 2021
  • Shafiq M, Jagavelu K, Iqbal H, Yadav P, Chanda D, Verma NK, Ghosh JK, Gaestel M, Hanif K. Inhibition of Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinase 2 (MK2) is Protective in Pulmonary Hypertension. Hypertension. Hypertension 2021
  • Srivastava N, Mishra S, Iqbal H, Chanda D, Shanker K. Standardization of Kaempferia galanga L. rhizome and vasorelaxation effect of its key metabolite ethyl p-methoxycinnamate. Journal of Ethnopharmacology 2021

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