Last Updated: Monday, 22 October 2018
Improved new processes, methods and techniques
S.No Title Inventors and Team Country/Patent No./Grant Date Summary
         
 1 A process for chemical conversion of isolated cellulose from aromatic spent biomass to hydroxy methyl furfural
PK Rout,
AD Nannaware,
Ram Rajasekharan
 
 USA/9199956/1.12.2015
 
The invention relates to the development of green process for the preparation of hydroxymethyl furfural (HMF) from cellulose isolated from spent aromatic biomass. HMF is a key intermediate substance useful as substitute of petro chemicals. As cellulose is the major constituent (40-50%) of the spent aromatic biomass (hemicellulose, 25-30% and lignin 15-20%) it is being used for synthesis of HMF. The synthesis of HMF from isolated cellulose is  an economical process and is completely environment-friendly which describes the development of sustainable, integrated and holistic strategy for utilizing the waste aromatic biomass to produce various valuable bio-chemicals.
 
2 Improved process for the isolation of 'calliterpenone-a’ natural plant growth promoting phyllocladane diterpenoid from genus Callicarpa
AK Singh,
SPS Khanuja,
Sudeep Tandon,
Alok Kalra,
D Sahoo,
AP Kahol,
MM Gupta,
RK Verma,
AK Kukreja,
Mansoor Alam,
GD Bagchi,
RP Bansal,
MP Darokar,
AK Gupta,
Australia/2006340617/6.3.2014
USA/7527814/5.5.2009
South Africa/2008/8011/26.8.2009
 
 The invention provides a simple method for isolation of calliterpenone a phyllocladane di-terpenoid with the plant growth regulating properties, from plant genus Callicarpa
 
 3 Process for isolation of withaferin-A from plant materials and products therefrom
RS Sangwan,
ND Chaurasiya,
LN Misra,
Payare Lal,
GC Uniyal,
NS Sangwan,
Avdhesh K Srivastava,
Krishan Avtar Suri,
Ghulam Nabi Qazi,
Rakesh Tuli
US/7108870/19.9.2006
India/244612/13.12.2010
 
An improved process of analytical and quantitative isolation of withaferin-A from Withania somnifera and other plants has been developed in which extraction solvent system consisting of a defined admixture of water and alcohol (preferably 60% alcohol and 40% water) for the dry plant material and from 60% to 80% alcohol for fresh plant material. The invented extract composition lead to better / improved yields and accurate quantitative estimations of withaferin A existent in plants or in material. The new process is valuable and advantageous for standardization of botanicals and metabolomic characterization of plants.
 
4 An improved process for the production of brevifoliol from Taxus wallichiana
SK Chattopadhyay,
Sachin Srivastava,
AS Negi,
TRS Kumar,
Ankur Garg,
SPS Khanuja 
USA/7579491/25.8.2009
Great Britain/1572618/18.6.2014
India/235045/24.6.2009
The invention provides an economic process for large scale production of an anticancer taxoid “brevifoliol” from plants belonging to the genus Taxus.
 
5

A process for isolation of bioactive hexane from Vetiveria zizaniodes pharmaceutical composition prepared therefrom.

 

SPS Khanuja,
Suchi Srivastava,
TRS Kumar,
MM Gupta,
AK Tripathi,
Monika Singh,
JR Bahl,
RK Lal,
MP Darokar,
AK Shasany,
Sushil Kumar
 
India/231854/12.3.2009
 
The present invention relates to a hexane bioactive fraction obtained from the roots of an aromatic plant named Vetiveria zizanioides commonly found in India for inhibiting the growth of drug resistant bacterial infections in humans and animals. It also relates to a pharmaceutical composition comprising the bioactive extract with other additives for inhibiting the growth of drug resistant bacterial infections in humans and animals and a process for the isolation of said bioactive extract.
 
6 Process for the preparation of novel growth media from distillation and other plant wastes for mass multiplication of bio-control fungi  HB Singh,
Alok Kalra,
NK Patra,
Sushil Kumar,
Rakesh Pandey,
SPS Khanuja,
AK Shasany
USA/6511821/28.1.2003
India/197203/23.6.2006
 
The invention relates to a process for the preparation of novel growth media from distillation and other medicinal plant wastes for mass production of bio-control fungi viz. Trichoderma harzianum and Gliocladium viride which are used for the control of plant diseases. Survival of these fungi on storage is significantly higher on this growth medium and its incorporation into soil greatly enhances its fertility status.
 
7 Process for the production of important taxol analogues 10-deacetyl taxol A,B and C
SK Chattopadhyay,
RP Sharma,
Sushil Kumar,
USA/6028206/22.2.2000
 
The invention provides to an improved process for the production of high yield of important taxol analogues 10-deacetyl taxols A, B&C under non acidic conditions and without using higher temperature steps as in the prior art.
 
8 Process for one pot conversion of artemisinin into artellnic acid
RS Bhakuni,
Tarun Singh,
Rinku Singh,
AP Kahol,
SPS Khanuja
 
 
India/258450/9.1.2014
 
The invention relates to an improved process for one pot conversion of artemisinin into artelinic acid, which reduces the three step (Three pots) conversion of artemisinin to artelinic acid in one step (one pot). Artelinic acid and sodium artelinate are customary names for p[(12-dihydroartemisininoxy)methyl] benzoate and sodium p-[12-dihydroartemisininoxy]methyl] benzoate, respectively. The sodium artelinate is considered to be best candidate drug amongst the available water soluble analogues of this class for the treatment of multi drug resistant and cerebral malaria.
 
 9 Primers and a screening method for identification of artemisinin producing plants
SPS Khanuja,
Shilpi Paul,
AK Shasany,
MP Darokar,
AK Shukla,
MM Gupta,
Anuruddha Kumar 
 India/234832/17.6.2009
 
The invention relates to a pair of primers and screening method for early identification of plants of Artemisia annua having high content of artemisinin.
 
 10 An improved economical process for the isolation of hepatoprotective agent oleanolic acid from Lantana camara
SK Srivastava,
Merajuddin Khan,
SPS Khanuja,
 
 India/232584/19.3.2009 Highly economical process has been developed for the isolation of oleanolic acid from the roots of Lantana camara which completely omits the use of expensive and highly tedious column chromatography and gives 1% yield which is three times more than the previously reported methods (US Patent No. 6,884, 908). Whole root biomass can be used in the new method as only root bark could be used in previous reports thereby making it further economical. Use of single solvent for extraction is also beneficial as solvent can be reused and/or recycled.  The method uses simple precipitation and crystallization processes which are easy, quick and highly economical.
 
11 Single pot conversion of artemisinin into artesunic acid
RS Bhakuni,
AP Kahol,
Tarun Singh,
SPS Khanuja 
India/234269/14.5.2009

The present invention provides a single pot process for the preparation of artesunic acid from artemisinin involving reduction followed by etherification of the reduced product at room temperature. The conversion of artemisinin into crude artesunic acid followed by workup and purification to yield pure product takes 6-10 hours as compared to previously reported methods (about 24-72 hours) and thus is less time consuming. The yield of final product in the present invention i.e. pure artesunic acid it upto 96% (w/w).

 
 12 Single pot conversion of artemisinin into arteether
RS Bhakuni,
Amit Tiwari,
Tarun Singh,
SPS Khanuja 
 
India/234267/14.5.2009
 
The present invention provides a method for the preparation of arteether from artemisinin in one pot in just about 4 hours comprising reduction of artemisinin into dihydroartemisinin by less quantity of sodium borohydride in ethanol at room temperature in the presence of a novel polyhydroxy catalyst.
 
 13 Single pot conversion of artemisinin into artemether 
RS Bhakuni,
Tarun Singh,
AP Kahol,
Amit Tiwari,
Sudeept Tandon,
SPS Khanuja
 
India/224810/22.10.2008
 
The invention relates to an improved method for the preparation of artemether which is useful for the treatment of uncomplicated, severe complicated and multi-drug resistant malaria. The previous methods carry some disadvantages being less cost effective and more time consuming as compared to the present invention. Moreover, benzene, a carcinogenic solvent used in the previous methods is not acceptable according to the health standards. Further, all the previous methods require at least two separate steps to convert artemisinin into ethers i.e. reduction of the artemisinin into dihydroartemisinin in the first pot followed by isolation of dihydroartemisinin and then comes the second step of conversion of dihydroartemisinin into different ethers in the second pot. However, the present invention provides an efficient method for conversion of artemisinin into artemether in one pot in just 4 hours as compared to 24-72 hours in previous methods.
 
 14 A process for the production of a food flavoring compound maltol from the leaves of plant of Genus abies
SK Chattopadhyay,
Sachin Srivastava,
KV Sashidhara,
Vinay Tripathi,
Sushil Kumar
 
India/194363/10.2.2006
 
The invention relates to highly economic process capable of commercial isolation of a food flavoring compound maltol from plant parts of the grass Abies without using chromatographic separation methods and other extreme conditions.
 
 15 An efficient method for the faster multiplication of earthworms and production of superior quality vermin-compost from the distillation waste of industrial aromatic crops
Alok Kalra,
Sushil Kumar,
Neetu Katiyar,
JR Bahl,
RP Bansal,
HC Singh,
Arun Prasad, 
Rakesh Panday,
OP Dhawan,
Alok Krishna,
Ramesh Srivastava
 
India/231000/28.2.2009
 
The invention related to a novel and efficient method for the faster production of superior quality vermicompost from the distillation wastes of aromatic/medicinal crops which have otherwise no economic value and are also not preferred by animals. No pre decomposition is required and compost developed by this method contains higher concentration of micro as well as macro nutrients. This method is significantly quicker and the process also results in the rapid multiplication of worms, thereby leading to production of vermicompost with higher nutrient status.
 
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